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Molecular mechanism of urea transport in the mammalian colon
Reference
D10935
Principal Investigator / Supervisor
Dr Craig Smith
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
233,760
Status
Completed
Type
Research Grant
Start date
01/01/2000
End date
31/05/2003
Duration
41 months
Abstract
Salvaging of urea nitrogen is an important means of nitrogen conservation in mammals. Urea circulating in the blood enters the colon where it is hydrolysed by resident microflora, liberating CO2 and ammonia. Ammonia is then absorbed and becomes available for a variety of biosynthetic processes, including synthesis of amino acids. A major influence on the recycling pathway is the rate at which urea diffuses across the colonic epithelium. Specialised transporter proteins regulate urea diffusion in the kidney and we have identified homologues of these proteins in colon. Our hypothesis is that these proteins form part of the mechanism regulating urea diffusion into the colon. We aim to identify and characterise colonic urea transporters in both mouse and human and to study their regulation in response to altered diet and water intake.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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