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Award details
Control of BipA and its stress- and virulence-related targets in Salmonella
Reference
D10913
Principal Investigator / Supervisor
Professor David O'Connor
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Centre for Biological Sciences
Funding type
Research
Value (£)
200,263
Status
Completed
Type
Research Grant
Start date
01/09/1999
End date
31/08/2002
Duration
36 months
Abstract
Recent studies have uncovered a novel GTPase, BipA, that regulates multiple virulence- and stress-related processes in enteropathogenic Escherichia coli. The aims of the proposal are: (i) to identify proteins and environmental conditions that control the expression of the Salmonella homologue of BipA, (ii) to identify additional downstream targets of BipA and (iii) to define in molecular terms the regulatory mechanism used by BipA. The combined genetic and proteomic studies will deepen our understanding of how stress adaptation and virulence are co-ordinately regulated in an important food-borne pathogen. The information obtained will also aid the identification of conditions that reduce bacterial virulence and/or viability and may be of use in the rational construction of live vaccine strains.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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