Award details

Investigation of the molecular mechanisms by which dietary fat integrates cholesterol homeostasis in the liver

Reference	D10211
Principal Investigator / Supervisor	Dr J Higgins
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	153,426
Status	Completed
Type	Research Grant
Start date	01/10/1998
End date	01/04/2002
Duration	42 months

Abstract

Plasma cholesterol levels are modulated by the total fat content and the fatty acid composition of the diet. The liver plays a central role in the determination of plasma cholesterol levels. Our hypothesis is that dietary fats influence cholesterol homeostasis in the liver by altering the putative intracellular cholesterol regulatory pool. This regulates the release of the active form of the sterol regulatory element binding protein, which in turn regulates gene expression of key proteins involved in cholesterol intracellular transit, uptake, synthesis and secretion. We aim to combine the approaches of biochemistry, cell biology and molecular biology to identify the cholesterol regulatory pool in liver, determine how it is altered by the amount and composition of dietary fats, and investigate the integration of cholesterol metabolism at the level of gene expression. (Joint with grant D10227).

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

D10227 Investigation of the molecular mechanisms by which dietary fat integrates cholesterol homeostasis in the liver

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