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Regulation of insulin-like growth factor binding proteins in the bovine ovary; key factors in follicle growth and selection
Reference
D10179
Principal Investigator / Supervisor
Professor Robert Webb
Co-Investigators /
Co-Supervisors
Dr David Armstrong
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
233,700
Status
Completed
Type
Research Grant
Start date
18/01/1999
End date
31/05/2002
Duration
40 months
Abstract
The overall aim is to determine the role of the ovarian insulin-like growth factor (IGF) system in the control of ovarian function in cattle. IGF's have a key role in modulating the response of antral follicles to gonadotrophins and the bioactivity of IGF's are regulated by the action of locally produced IGF binding proteins (IGFBPs). The proposed study will investigate the action of IGFBPs and their proteases at precise functional stages of antral follicle growth and selection. This will be achieved by determining the role of IGFBP proteases in the post-translational modification of IGFBP-2 and -4 and its effect on IGF bioactivity. The properties of the IGFBP proteases will be characterised and their cellular origin in bovine follicles determined. The identity of the factors involved in regulating the activity of IGFBP-2 and -4 protease activity will also be elucidated.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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