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Interaction between the influence of genomic variability and n-3 polyunsaturated fatty acid intake on TNF-a production

Reference	D09831
Principal Investigator / Supervisor	Professor Robert Grimble
Co-Investigators / Co-Supervisors	Professor Philip Calder
Institution	University of Southampton
Department	Development Origin of Health and Disease
Funding type	Research
Value (£)	307,765
Status	Completed
Type	Research Grant
Start date	01/12/1998
End date	31/12/2001
Duration	37 months

Abstract

Tumour necrosis factor-alpha (TNF-alpha) is important for normal immune function but is also linked with inflammatory disease. Production is influenced by polymorphisms in the TNF-alpha and TNF-beta genes, by HLA characteristic and by the intake of polyunsaturated fatty acids (PUFAs). n-3 PUFAs suppress TNF-alpha production. The TNF2 and TNFB2 genes and HLA class II DR3 or DR4 haplotypes are linked to raised TNF-alpha production and inflammatory disease. Nationally, an increase in intake of n-3 PUFA is recommended. The effect of this dietary change on TNF-alpha production in people, with differing genotypes, is unknown. This issue will be studied by adding fish oil to the diet of young males, measuring TNF-alpha production by blood mononuclear cells before and after fish oil, and relating changes in production to the subjects genome, characterised by polymorphisms in TNF genes and HLA antigens.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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