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Award details
Role of IL12 in pathogenesis and immunity to Salmonella
Reference
D09737
Principal Investigator / Supervisor
Professor Gordon Dougan
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
190,315
Status
Completed
Type
Research Grant
Start date
02/10/1998
End date
02/10/2001
Duration
36 months
Abstract
Salmonella infections affect humans and animals world-wide. This project will analyse the role of IL12 in resistance to enteric fever using the murine typhoid model. The sites and time course of IL12 production in the tissues will be studied. The mechanisms by which IL12 controls bacteria growth will be investigated in mice treated with anti-IL12 antisera and in Il12 KO mice. The role of IL12 in the development of protective T and B-cell memory induced by vaccination will be analysed in conventional and IL12 KO mice. Both immunological and molecular techniques will be used. The proposed work will provide fundamental immunological knowledge towards a more rational therapy of salmonellosis and for the development of improved vaccines.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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