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Award details
The elucidation of the biochemical pathway leading to the synthesis of (-)-epicatechins in plants
Reference
D09706
Principal Investigator / Supervisor
Professor Rod Casey
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
Metabolic Biology
Funding type
Research
Value (£)
187,984
Status
Completed
Type
Research Grant
Start date
01/07/1998
End date
01/07/2001
Duration
36 months
Abstract
This proposal extends the results of a previous project on plant dioxygenases jointly funded by BBSRC and industry, which uncovered the probable progenitor enzyme leading to the synthesis of (-)-epicatechins in plants. The objective of this work is to identify all of the genes and enzymes involved in the synthesis of the (-)-epicatechin components of proanthocyanidins. This involves testing whether enzymes already identified as being involved in the synthesis of (+)-catechins are also able to utilise 2,3-cis- isomers of their substrates, the cloning of cDNAs encoding novel enzyme activities and the expression and assay of recombinant proteins.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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