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Protection of intestinal epithelium against dietary mutagens by biologically active food components: effects on TNF signalling and apoptosis
Reference
D09671
Principal Investigator / Supervisor
Professor Frederick Campbell
Co-Investigators /
Co-Supervisors
Professor John Mathers
,
Professor Craig Robson
Institution
Queen's University of Belfast
Department
Sch of Medicine, Dentistry & Biomed Sci
Funding type
Research
Value (£)
121,226
Status
Completed
Type
Research Grant
Start date
01/01/1999
End date
01/01/2002
Duration
36 months
Abstract
Curcumin and Phenylethyl-3-methylcaffeate (PEMC) are food components which promote apoptosis in vitro and protect against azoxymethane induced carcinogenesis in vivo, by unknown mechanisms. This study will test the hypotheses that (i) Curcumin and PEMC promote intestinal epithelial apoptosis by modulation of TNF- alpha signalling pathway and (ii) that this pathway is related to their protective activity. Effects of food components on (i) TNF related gene expression and apoptosis in vitro and in vivo and (ii) carcinogen induced tumorigenesis, will be sought. A human TNF responsive cell line, the MIN mouse model of human tumorigenesis and the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo (4,5-b)pyridine, will be used. This study will investigate molecular mechanisms of intestinal protection by biologically active food components.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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