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The Campylobacter jejuni RacR regulatory system: characterising the regulon and its role in adaptive responses and intestinal colonisation
Reference
D09207
Principal Investigator / Supervisor
Professor Julian Ketley
Co-Investigators /
Co-Supervisors
Institution
University of Leicester
Department
Genetics
Funding type
Research
Value (£)
171,133
Status
Completed
Type
Research Grant
Start date
28/02/1998
End date
28/02/2002
Duration
48 months
Abstract
The Campylobacter jejuni RacR regulatory system has a role in adaptation to environmental conditions found in the intestine. RacR is a member of the two component family of transcriptional regulators. The phenotype of a racR mutant includes an altered pattern of growth at both 37 and 42 Degrees Celcius and a reduced ability to colonise the chicken intestine. The objective of this proposal is to further characterise this regulatory system and investigate the members of the cognate regulon with a view to determining the role of the system in the physiology and virulence of campylobacters. The proposed work has three main aims: (1) characterise RacS, the putative cognate protein kinase; (2) identify members of the RacR regulon and determine the role of each locus; and (3) investigate the signals to which the RacRS system responds and characterise the regulation of racRS expression.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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