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Novel methods for nanomechanical spectroscopy of specific protein interactions and single protein molecules
Reference
D08752
Principal Investigator / Supervisor
Professor Mervyn Miles
Co-Investigators /
Co-Supervisors
Professor Peter Shewry
,
Dr Arthur Tatham
Institution
University of Bristol
Department
Physics
Funding type
Research
Value (£)
140,887
Status
Completed
Type
Research Grant
Start date
01/09/1998
End date
01/09/2001
Duration
36 months
Abstract
The atomic force microscope will be used to conduct force spectroscopy experiments on specific protein:protein interactions and on single protein molecules. Tethering the molecules to tip and surface, the forces between monomeric gluten proteins will be measured as a function of temperature and ionic environment, in order to determine the relative roles of hydrogen bonding and hydrophobic interactions. Single protein molecules bridging the tip and surface will be subjected to linear and cyclic strains, in different ambient conditions, to elucidate the molecular viscoelastic response. The knowledge gained at the molecular level will be used to understand the physical behaviour of gluten networks and wheat doughs.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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