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The effects of dietary Gal-GalNAc-binding lectins on intestinal epithelial metabolism & proliferation
Reference
D08258
Principal Investigator / Supervisor
Professor Jonathan Rhodes
Co-Investigators /
Co-Supervisors
Professor Barry Campbell
,
Dr Robert Goodlad
Institution
University of Liverpool
Department
Medicine
Funding type
Research
Value (£)
245,659
Status
Completed
Type
Research Grant
Start date
01/12/1997
End date
01/06/2001
Duration
42 months
Abstract
Dietary plant-derived lectins often resist digestion and could have a considerable impact on the proliferation and metabolism of intestinal epithelial cells to which they bind. In previous laboratory studies the applicants have shown that the lectins in peanuts and edible mushrooms cause marked increase and reduction respectively in the proliferation of human colon epithelial cells but further studies are now needed (a) to determine the in vivo effects of dietary lectin and its competing dietary carbohydrate and (b) to explore the intracellular mechanism for the biological effects of these non-cytotoxic lectins.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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