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The effects of dietary Gal-GalNAc-binding lectins on intestinal epithelial metabolism & proliferation

Reference	D08258
Principal Investigator / Supervisor	Professor Jonathan Rhodes
Co-Investigators / Co-Supervisors	Professor Barry Campbell, Dr Robert Goodlad
Institution	University of Liverpool
Department	Medicine
Funding type	Research
Value (£)	245,659
Status	Completed
Type	Research Grant
Start date	01/12/1997
End date	01/06/2001
Duration	42 months

Abstract

Dietary plant-derived lectins often resist digestion and could have a considerable impact on the proliferation and metabolism of intestinal epithelial cells to which they bind. In previous laboratory studies the applicants have shown that the lectins in peanuts and edible mushrooms cause marked increase and reduction respectively in the proliferation of human colon epithelial cells but further studies are now needed (a) to determine the in vivo effects of dietary lectin and its competing dietary carbohydrate and (b) to explore the intracellular mechanism for the biological effects of these non-cytotoxic lectins.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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