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The effects of dietary Gal-GalNAc-binding lectins on intestinal epithelial metabolism & proliferation

ReferenceD08258
Principal Investigator / Supervisor Professor Jonathan Rhodes
Co-Investigators /
Co-Supervisors
Professor Barry Campbell, Dr Robert Goodlad
Institution University of Liverpool
DepartmentMedicine
Funding typeResearch
Value (£) 245,659
StatusCompleted
TypeResearch Grant
Start date 01/12/1997
End date 01/06/2001
Duration42 months

Abstract

Dietary plant-derived lectins often resist digestion and could have a considerable impact on the proliferation and metabolism of intestinal epithelial cells to which they bind. In previous laboratory studies the applicants have shown that the lectins in peanuts and edible mushrooms cause marked increase and reduction respectively in the proliferation of human colon epithelial cells but further studies are now needed (a) to determine the in vivo effects of dietary lectin and its competing dietary carbohydrate and (b) to explore the intracellular mechanism for the biological effects of these non-cytotoxic lectins.

Summary

unavailable
Committee Closed Committee - Agri-food (AF)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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