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Regulation of cyclooxygenase and detoxification enzymes by dietary polyphenols in human colon cells
Reference
D08200
Principal Investigator / Supervisor
Professor John Hayes
Co-Investigators /
Co-Supervisors
Dr Lesley McLellan
Institution
University of Dundee
Department
Biomedical Research Centre
Funding type
Research
Value (£)
230,925
Status
Completed
Type
Research Grant
Start date
05/01/1998
End date
05/10/2001
Duration
45 months
Abstract
Evidence suggests that plant micronutrients which suppress the incidence of colon cancer, do so by enhancing endogenous detoxification systems and inhibiting the cytotoxic effects of cyclooxygenase activity. We propose to investigate the biochemical mechanisms underlying the chemopreventive effects of the naturally-occurring polyphenols, anthocyanidin, catechin, carnosol and genistein (found in fruit, vegetables, herbs and beverages), in human colon cells. The mechanisms by which these micronutrients a) enhance gene expression of antioxidant and detoxification proteins, and b) suppress the delerious effects of cyclooxygenase activity will be examined.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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