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Signalling mechanisms involved in lipid-induced CCK release from intestinal endocrine cells
Reference
D08146
Principal Investigator / Supervisor
Professor David Thompson
Co-Investigators /
Co-Supervisors
Professor Richard Case
,
Dr Geoffrey Warhurst
Institution
The University of Manchester
Department
Medical and Human Sciences
Funding type
Research
Value (£)
247,838
Status
Completed
Type
Research Grant
Start date
05/01/1998
End date
05/01/2001
Duration
36 months
Abstract
Cholecystokinin (CCK), released by mucosal endocrine cells in the upper intestine plays a central role in lipid digestion but the way in which lipids signal CCK release is unknown. We will study (I) the characteristics of fatty acid (FA) structure required for CCK release; (ii) the molecular basis of cell membrane/FA interactions; (iii) the intracellular signalling pathways involved in the stimulation of CCK release. Experiments will be performed both on a murine CCK producing cell line (STC-1) and on isolated human intestinal endocrine cells. The results will provide not only an understanding of the FA/CCK transduction process but also the means whereby human lipid intake and digestion can be manipulated.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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