Award details

Peyer's patch T cell responses to food antigens in man

Reference	D08112
Principal Investigator / Supervisor	Professor Thomas MacDonald
Co-Investigators / Co-Supervisors	Dr Peter Fairclough
Institution	Queen Mary University of London
Department	Queen Mary University of London Department
Funding type	Research
Value (£)	142,462
Status	Completed
Type	Research Grant
Start date	01/12/1997
End date	01/12/2000
Duration	36 months

Abstract

In this work, for the first time, the food antigen-specific response of Peyer's patch (PP) T cells naturally immunised through diet will be studied in man. T cells (and their CD4 and CD8 subsets) will be isolated from ileal biopsies of patients of different ages and their in vitro recall responses to cows milk and wheat antigens be characterised by ELISPOT, RT-PCR and flow cytometry to evaluate their Th1, Th2 profile. Anti-cytokine antibodies, recombinant cytokines and microbial products will be used to skew, suppress or enhance these responses. T cell lines and clones will also be established to determine the peptides recognised by PP T cells. These studies will directly address the factors which control the immunogenicity of foods in the gut.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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