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A novel approach to the study of the physiology and molecular basis of bacterial starvation-survival
Reference
D08052
Principal Investigator / Supervisor
Professor Simon J. Foster
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
166,783
Status
Completed
Type
Research Grant
Start date
05/05/1997
End date
05/05/2000
Duration
36 months
Abstract
Effective eradication of food-borne pathogens and spoilage bacteria requires detailed knowledge of the physiology and resistance properties of the organisms in the stressed food environment. The overall aim of the project is to understand the molecular mechanisms involved in starvation-survival and resistance in food-associated organisms. A novel approach based on cDNA and subtractive hybridisation technology will be used to identify starvation-specific genes expressed in Staphylococcus aureus. Those with important roles in long-term survival and resistance will be identified and analysed. The generic application of the novel method will be demonstrated in Listeria monocytogenes and common starvation- survival components identified. These components will provide the food and other industries with new targets for development of bacterial control mechanisms.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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