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The role of secreted proteins (sips) and their interactions with host cells in virulence of Salmonella
Reference
D07439
Principal Investigator / Supervisor
Dr Edouard Galyov
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Molecular Biology Pirbright
Funding type
Research
Value (£)
232,397
Status
Completed
Type
Research Grant
Start date
06/05/1997
End date
06/05/2000
Duration
36 months
Abstract
Salmonella proteins that are likely to be involved in adherence to, and penetration of, host cells and the control of intracellular growth and survival of the bacteria will be investigated. To understand how the disease develops and the methods by which Salmonella can obstruct the primary host defence, the role(s) of S. dublin secreted proteins (Sips) will be assessed. Proposed experiments include: i) Cloning, sequencing, and mutagenesis of S. dublin sip genes ii) Raising anti-Sip antibodies iii) Analysis of Sips activity and localisation in vitro iv) Analysis of the importance of SipB and other Sips for S. dublin virulence in mice v) Analysis of the role of Sip proteins in Salmonella - eukaryotic cell interactions.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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