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Comprehensive analysis of stationary phase survival regulons of Salmonella
Reference
D07416
Principal Investigator / Supervisor
Professor David O'Connor
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Centre for Biological Sciences
Funding type
Research
Value (£)
217,985
Status
Completed
Type
Research Grant
Start date
04/08/1997
End date
04/08/2000
Duration
36 months
Abstract
Entry into stationary phase, mediated in large part by the RpoS sigma factor, greatly enhances the resistance of Salmonella species to a variety of stresses, including starvation, hyperosmosis, oxidation, heat and low pH. Currently, however, less than 50% of the proteins induced in early stationary phase have been identified. To achieve a comprehensive analysis of such proteins in Salmonella typhimurium, high resolution two-dimensional gel electrophoresis and microsequencing will be employed. Genes encoding representative novel stationary phase-regulated proteins will be cloned and specifically mutated to assess their contribution to Salmonella survival in various food matrices.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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