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Can the metabolic effects of dietary n-3 PUFA be explained by changes in the expression of lipase genes in adipose tissue?
Reference
D06452
Principal Investigator / Supervisor
Professor Bruce Griffin
Co-Investigators /
Co-Supervisors
Dr Margaret Murphy
,
Professor Christine Williams
Institution
University of Surrey
Department
Health and Medical Sciences
Funding type
Research
Value (£)
288,216
Status
Completed
Type
Research Grant
Start date
01/01/1997
End date
01/03/2000
Duration
38 months
Abstract
Nutrient-gene interactions are thought to underlie the common development of insulin resistance which is associated with an atherogenic lipoprotein phenotype (ALP) and increased risk of coronary heart disease in man. We postulate that an ALP may arise from a defect in the removal of dietary fat from the circulation by lipoprotein lipase in adipose tissue and/or failure to suppress hormone sensitive lipase in the same tissue. We suggest that these effects may originate, in part, from low intakes of n-3 PUFA supplements will correct an ALP by influencing the genetic expression and thus activity of these lipases in human adipose tissue.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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