Award details

Infectivity and physiology of non-culturable cells of Salmonella typhimurium

Reference	D06412
Principal Investigator / Supervisor	Professor Michael Barer
Co-Investigators / Co-Supervisors	Professor Colin Harwood
Institution	Newcastle University
Department	School of Cell and Molecular Biosciences
Funding type	Research
Value (£)	233,703
Status	Completed
Type	Research Grant
Start date	05/08/1996
End date	31/03/2000
Duration	43 months

Abstract

Non-culturable forms of bacteria pose a major challenge in food microbiology as potential sources of infection. This project will determine the infectivity of non- culturable cells of Salmonella typhimurium formed by carbon/nitrogen (C/N) stress and the contribution such cells may make to the infective dose of mixed culturable/non-culturable cell populations. Use of a mouse model which has been established and refined for over 20 years, will enable us to resolve critical quantitative issues in regarding infectivity. To elucidate further the physiology of non- culturable bacteria, we will also study gene expression in C/N stressed cells. Specifically, we aim to determine how expression differs in cells which do not replicate in response to nutrient amendment from those that do and to search for genes which are expressed during transition between culturable and non-culturable states.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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