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Plant polyphenols in diet and health: factors influencing their absorption across the small intestine
Reference
D06405
Principal Investigator / Supervisor
Dr C Rice-Evans
Co-Investigators /
Co-Supervisors
Professor Godfrey Bolwell
,
Dr Edward Debnam
,
Professor Surjit Srai
Institution
King's College London
Department
Division of Biochemistry & Molecular Bio
Funding type
Research
Value (£)
265,073
Status
Completed
Type
Research Grant
Start date
01/10/1996
End date
01/10/1999
Duration
36 months
Abstract
The aims of this project are to identify the sites and extent of absorption of polyphenols in vivo, and their influence on iron absorption, with a view to identifying specific plant products as potential agents for enhancing the antioxidant properties of food. Radiolabelled modified phenolics will be synthesised by chemical and enzymic methylation and modified polyphenols by biotransformation using plant cell culture. Absorption of polyphenols and the influence of iron will be measured in vivo by quantifying lumen to blood transfer using the in situ loop technique. HPLC analysis of plasma uptake of phenolics will also be developed in parallel with the radiochemical studies.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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