Award details

An investigation of the effects of fatty acids and dietary lipids upon cytokine and adhesion molecule mRNA levels

Reference	D05696
Principal Investigator / Supervisor	Professor Philip Calder
Co-Investigators / Co-Supervisors
Institution	University of Southampton
Department	Development Origin of Health and Disease
Funding type	Research
Value (£)	218,604
Status	Completed
Type	Research Grant
Start date	24/06/1996
End date	24/06/1999
Duration	36 months

Abstract

It has been suggested that dietary lipid-induced effects upon lymphocyte functions are elicited through effects upon cytokine production and surface molecule expression. This project will examine this hypothesis by determining the effect of a range of fatty acids in vitro and of several dietary lipids upon the levels of mRNA for a variety of cytokines and adhesion molecules. Established techniques will be used to manipulate the fatty acid composition of human peripheral blood leucocytes, murine spleen lymphocytes and murine macrophages either in vitro or through the diet. Standard techniques will be used to isolate RNA and to quantify the levels of particular mRNA species; appropriate controls will be used. This project will provide important information about the mechanism of the immunomodulatory effects of dietary lipids and may help to explain why only certain types of fatty acids and dietary lipids are immunomodulatory.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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