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Transgenic Caenorhabditis elegans as a monitor for soil pollution
Reference
D05337
Principal Investigator / Supervisor
Dr David De Pomerai
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
133,020
Status
Completed
Type
Research Grant
Start date
01/11/1995
End date
01/11/1998
Duration
36 months
Abstract
We have developed a method for rapid assessment of aquatic toxicity (8h), based on the response of stress-inducible reporter genes in transgenic C. elegans (ref 5). The proposed project will adapt this method for assessing soil toxicty, since C. elegans is a soil nematode. We will optimise conditions for culturing C. elegans and food bacteria in soil, for recovering worms and for exposing worms to test toxicants. We will examine the variability in response within worm populations, and also compare different routes of exposure. In the second year, we will evaluate this system using OECD standard soil supplemented with metals or selected agrochemicals, and in the third year will repeat this work using several standard soil types.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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