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Cell mediated immune mechanisms in salmonellosis
Reference
D04785
Principal Investigator / Supervisor
Professor Carlos Hormaeche
Co-Investigators /
Co-Supervisors
Professor John Robinson
Institution
Newcastle University
Department
School of Cell and Molecular Biosciences
Funding type
Research
Value (£)
237,822
Status
Completed
Type
Research Grant
Start date
01/01/1997
End date
31/12/2000
Duration
45 months
Abstract
The role of cell mediated immunity, with special reference to cytotoxic T-cells (CTLs), in protection conferred by live attenuated salmonella vaccines will be studied in the mouse typhoid model with views to improved vaccine development. CTLs induced by immunisation with Aro Salmonella typhimurium and S. enteritidis vaccines will be studied using different salmonella-infected cells as targets to investigate their correlation with protective immunity and their contribution to the serotype-specific protection conferred by vaccination. At a later stage, we will attempt to define the identity of the Salmonella antigens recognised by CTLs.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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