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Analysis of the role of chromobox-containing genes from yeast (Saccharomyces cerevisiae) in heritable gene repression
Reference
D01809
Principal Investigator / Supervisor
Professor Mark Fricker
Co-Investigators /
Co-Supervisors
Dr E Mellor
Institution
University of Oxford
Department
Plant Sciences
Funding type
Research
Value (£)
236,760
Status
Completed
Type
Research Grant
Start date
26/09/1994
End date
04/12/1997
Duration
41 months
Abstract
The heterochromatic associated protein HP1 from Drosophila has been shown to be able to repress gene expression. Several genes have been isolated from other eukaryotes (mouse, human, mealybug) that are remarkably homologous to HP1, each has a 37 amino acid motif known as the chromobox. Therefore it is highly likely that HP1-like proteins are responsible for gene repression events in many eukaryotes. We have evidence for the existence of a chromobox gene in Saccharomyces cerevisiae. We propose to isolate and analyse this gene (ScCBX), to identify interacting proteins and their chromosomal distribution, and to use the tractable genetics of this organism to elucidate the role of HP1 proteins in chromatin organization in all eukaryotes.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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