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The role of integrins in morphogenesis and differentiation of mammary gland
Reference
D01795
Principal Investigator / Supervisor
Professor Charles Streuli
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
196,590
Status
Completed
Type
Research Grant
Start date
22/09/1994
End date
22/03/1998
Duration
42 months
Abstract
In mammary gland, epithelial cells form arborating ductal networks during foetal and postnatal development, and differentiate into secretory alveolar lobules in pregnancy. These events depend on interactions with the extracellular matrix through adhesion receptors such as integrins. The proposed studies will advance our understanding of the molecular signals that control the morphogenesis and differentiation of mammary epithelium. The specific aims are i) to analyze the spatial and temporal pattern of integrin expression during mouse mammary gland development by immunohistochemistry and in situ hybridisation, and ii) to dissect integrin function in vivo by expressing antisense or mutated integrin cDNAs in chimeric mammary gland transplants.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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