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Award details
Molecular and cellular development of adipose tissue in the perinatal lamb
Reference
D01715
Principal Investigator / Supervisor
Professor Michael Lomax
Co-Investigators /
Co-Supervisors
Dr Michael Symonds
Institution
University of Aberdeen
Department
Agriculture and Forestry
Funding type
Research
Value (£)
114,370
Status
Completed
Type
Research Grant
Start date
01/10/1994
End date
31/12/1997
Duration
38 months
Abstract
Non-shivering thermogenesis (NST) in brown adipose tissue (BAT) is dependent on the synthesis and activation of uncoupling protein (UCP). In ruminants, BAT and the ability to prevent hypothermia via NST both decline rapidly after birth, but the mechanisms responsible for this biochemical programming are unknown. This project aims to determine the age at which the postnatal loss of UCP expression occurs in different adipose tissue depots, whether the process is irreversible, and the extent to which it can be manipulated. Biochemical investigations on adipose tissues will be paralleled by immuno-histochemistry and in situ hybridisation studies on adipocyte populations.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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