Award details

Lipid-induced cholecystokinin-vagus interactions in man: molecular basis and functional consequences

Reference	D01671
Principal Investigator / Supervisor	Professor David Thompson
Co-Investigators / Co-Supervisors	Dr R Dimaline, Professor Graham Dockray
Institution	The University of Manchester
Department	Medical and Human Sciences
Funding type	Research
Value (£)	239,956
Status	Completed
Type	Research Grant
Start date	01/09/1994
End date	01/09/1997
Duration	36 months

Abstract

This multidisciplinary project will test the hypothesis that human upper gastrointestinal responses to ingested fat are neurally mediated by a vago-vagal pathway initiated by CCK release from the intestine mucosa. In vivo studies will determine relationships between lipid structure, gastric responses, circulating levels of CCK, and vagal afferent neuron integrity. In vitro studies will determine (i) relationships between lipid structure, intestinal CCK biosynthesis and its release; (ii) the structure of the human vagal CCK receptor, its axonal transport and its binding characteristics. These experiments will permit new strategies to be developed for modifying the gastrointestinal processing of food by manipulation of dietary lipid composition.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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