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The role of bacterial endospore cell wall structure during differentiation and the maintenance of heat resistance
Reference
D01664
Principal Investigator / Supervisor
Professor Simon J. Foster
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
135,699
Status
Completed
Type
Research Grant
Start date
01/09/1994
End date
01/09/1997
Duration
36 months
Abstract
Highly heat resistant, dormant, bacterial endospores pose a huge problem to the food preservation industry. Dormancy and heat resistance are maintained by the spore cortex. Cortex fine structure will be determined by HPLC separation of peptidoglycan digests followed by mass spectrometry of the products. Cortex Bacillus subtilis 168 mutants. Peptidoglycan analyses during differentiation will reveal how the cortex is synthesized, its involvement in setting up the dormant state and how it is hydrolysed during germination. This work will allow the evaluation of existing and potential new sporicidal treatments which may affect cortex structure.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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