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Growth hormone signalling and cross-talk in adipocytes
Reference
D01555
Principal Investigator / Supervisor
Professor Miles Houslay
Co-Investigators /
Co-Supervisors
Dr Neil Anderson
Institution
University of Glasgow
Department
IBLS Division of Biochemistry & Molecula
Funding type
Research
Value (£)
159,206
Status
Completed
Type
Research Grant
Start date
01/10/1994
End date
01/10/1997
Duration
36 months
Abstract
Growth hormone modulates both differentiation and metabolism of adipocytes through changes in gene transcription and alterations in the functioning of other signalling systems; the mechanism whereby these changes are induced are unknown. We aim to define cross- talk occurring between the growth hormone and the protein kinase C and cyclic AMP signalling systems. We intend to determine; (a) the role of protein kinase C isoforms in growth hormone signalling and interactions, (b) the mechanisms whereby growth hormone modulates the activity of the G-protein, G2, adenylyl cyclase and cyclic AMP phosphodiesterase isoforms, key components of the cyclic AMP system.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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