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Investigation of the molecular mechanisms by which dietary fish-oils modulate VLDL secretion and LDL uptake by the liver
Reference
D01149
Principal Investigator / Supervisor
Dr J Higgins
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
137,932
Status
Completed
Type
Research Grant
Start date
01/09/1994
End date
30/04/1998
Duration
43 months
Abstract
A number of investigations have shown that dietary fish-oils (n-3 fatty acids) have a beneficial effect in preventing atherosclerosis. The main reproducible effect of addition of fish-oils to the diet of humans or laboratory animals is a reduction by more than 50% of the circulating levels of plasma very low density lipoprotein-triacylglycerol (VLDL- TAG). This is not due to a change in triacylglycerol synthesis but to modulation of VLDL production by the liver. The aims of the proposed study are to investigate the molecular mechanisms by which dietary fish-oils alter the intracellular events in VLDL assembly and secretion. As such studies cannot be performed on humans we will use rabbits and hamsters as animal models.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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