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Award details
Novel production of plant viral antigens using comoviruses as vectors
Reference
CW206422
Principal Investigator / Supervisor
Dr Andrew King
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Molecular Biology
Funding type
Research
Value (£)
123,481
Status
Completed
Type
Research Grant
Start date
01/03/1994
End date
01/08/1998
Duration
53 months
Abstract
The objectives of this project are:1) to demonstrate that experimental vaccines consisting of chimaeric CPMV particles containing an FMDV epitope and other animal epitopes can protect animals against challenge with FMDV (to be conducted at the Institute of Animal Health, Pirbright).2) to develop a series of constructs containing epitopes derived from FMDV and HIV-1 and biologically active peptides and provide them in sufficient quantities for testing. Design vectors which contain insertion sites at other loops and the C-terminus (to be conducted at the John Innes Centre under award CW206285)3) to establish a core competence in the technology at Babraham, such that constructs can be engineered to incorporate epitopes and peptides and chimaeric virus particles can be produced and purified. To develop a production system that conforms to regulatory and industrial standards, obtain data on the yield of chimaeric virus in cowpea plants and establish collaborations with third parties (to be conducted by AXIS Genetics under award CW206285).
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
CWIS - Chemicals & Pharmaceuticals Directorate (CW2) [1989-1993]
Funding Scheme
X – not Funded via a specific Funding Scheme
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