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Enzymatic methods for the enantioselective synthesis of novel alpha-hydroxy acids alpha-amino acids and polyhydroxylated compounds
Reference
CS05318
Principal Investigator / Supervisor
Professor Chris Willis
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Chemistry
Funding type
Research
Value (£)
136,623
Status
Completed
Type
Research Grant
Start date
22/01/1996
End date
22/01/1999
Duration
36 months
Abstract
Methods will be developed for the efficient synthesis of a range of functionalised alpha-keto acids which will be examined as substrates for commercially available D- and L-LDHs and amino acid dehydrogenases as well as genetically engineered LDHs. The resultant novel alpha-hydroxy acids and alpha-amino acids will be used in the preparation of combinatorial libraries as well as building blocks to more complex molecules such as polyhydroxylated compounds and azosugars. The viability of combining several biotransformations on one-pot will be investigated.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Clean Synthesis - CPD (CS) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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