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Poly-amino acids as chiral catalysts
Reference
CS05304
Principal Investigator / Supervisor
Professor Stanley Roberts
Co-Investigators /
Co-Supervisors
Professor Jennifer Littlechild
,
Dr B Ridge
Institution
University of Liverpool
Department
Chemistry
Funding type
Research
Value (£)
194,829
Status
Completed
Type
Research Grant
Start date
06/02/1996
End date
31/12/1999
Duration
47 months
Abstract
Investigation of the scope, potential, and underlying mechanism of chiral synthesis catalysed by poly-amino acids. Study of the influence of poly-amino acids and of block sequential polypeptides (related to collagen and the silk fibroin) on the chiral selectivity of palladium-catalysed asymmetric hydrogenation, platinum catalysed oxidation, and Lewis acid catalysed cyclo-additions. The biopolymers will be synthesised using recombinant DNA techniques and solid phase peptide synthesis. The mechanism of chiral discrimination will be studied by varying the amino acid side-chain, the chain length, and chirality of the polymer and studying phase behaviour.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Clean Synthesis - CPD (CS) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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