Award details

Tbx20 orthologues and the generation of morphological diversity

Reference	COD16764
Principal Investigator / Supervisor	Professor Jane Sowden
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Institute of Child Health
Funding type	Research
Value (£)	114,476
Status	Completed
Type	Research Grant
Start date	01/02/2003
End date	30/06/2005
Duration	29 months

Abstract

This joint proposal aims to investigate how Tbx20 orthologues have been recruited to the development of diverse body structures during evolution. The C. elegans Tbx20 orthologue, mab-9, is an important regulator of hindgut development, while vertebrate and Drosophila Tbx20 genes are postulated to play a role in heart formation. We will use C. elegans to investigate the extent of conservation of worm and mouse Tbx20 function. We will also examine whether Tbx20/mab-9 genetic pathways are conserved between mouse and nematode. Expression of Tbx20 will be analysed in the primitive chordate, Ciona intestinalis in order to explore its role in evolution of the primitive heart. Thus, a comparative approach is proposed to investigate the biology of this important group of genes, designed to answer evolutionary questions about the generation of morphological diversity. (Joint with grant 43/COD16763).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Comparative Development Initiative (COD) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

COD16763 Tbx20 orthologues and the generation of morphological diversity

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