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Hagfish homeobox genes and the basal vertebrate development toolkit
Reference
COD15495
Principal Investigator / Supervisor
Professor Peter Holland
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Zoology
Funding type
Research
Value (£)
255,844
Status
Completed
Type
Research Grant
Start date
01/08/2002
End date
31/07/2005
Duration
36 months
Abstract
Hagfish may represent the most basal of all vertebrate lineages, yet they have been neglected by comparative developmental and genomic studies. Starting with an EST survey of Atlantic hagfish genes, we will attempt to resolve the controversial phylogenetic position of hagfish. We will then construct and sequence partial genomic maps for the Hox gene clusters of hagfish, and compare Hox gene composition and sequence evolution to other vertebrates and amphioxus. These analysis, plus cloning of other genes, will give insight into alternative pathways of vertebrate genome evolution and will be used to test whether two rounds of tetraploidy occurred in early vertebrate evolution, during establishment of a basal and fundamental developmental genetic toolkit for vertebrates.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Comparative Development Initiative (COD) [2001]
Funding Scheme
X – not Funded via a specific Funding Scheme
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