Award details

Connecting genome to process : the linkage of saccharopolyspora erythrea metabolic engineering to product flux

Reference	CFB17700
Principal Investigator / Supervisor	Professor John Ward
Co-Investigators / Co-Supervisors	Dr Frank Baganz
Institution	University College London
Department	Structural Molecular Biology
Funding type	Research
Value (£)	396,104
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	01/04/2007
Duration	48 months

Abstract

The objective is to bring together molecular genetics (Cambridge, UCL), metabolic modelling (Oxford, UCL) and experimental studies (UCL) of Saccharopolyspora erythaea to create a foundation for the production of novel antibiotics at realistic titres. The project will complement and draw upon research on Streptomyces coelicolor. The proposed research addresses the interdisciplinary objectives of the Manufacturing and Post Genomic Technologies Initiative and the global challenge of dealing with drug resistant pathogens. The metabolic model which results will link primary metabolism to secondary metabolism and be generally applicable to the main antibiotic producing organisms. (Joint with grants 17699 and 17702).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Cell Function to Bioprocessing (CFB) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

CFB17699 Connecting genome to process : the linkage of S erythraea metabolic engineering to product flux

CFB17702 Connecting genome to process : the linkage of primary precursors to secondary metabolites

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