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Agonist-specific coupling and insect neuropeptide receptors
Reference
CEL04739
Principal Investigator / Supervisor
Dr Peter Evans
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
143,658
Status
Completed
Type
Research Grant
Start date
01/02/1996
End date
01/04/1999
Duration
38 months
Abstract
Molecular biological approaches will be used to clone receptors activated by endogenous neuropeptides of the Phe-Met-Arg-Phe-NH2 (FMRFamide) family from the central nervous system and skeletal muscle of the desert locust, Schistocerca gregaria. The potential capacity of the nervous system to express different endogenous neuropeptides of this family will be assessed by cloning and sequencing cDNAs encoding their polyprotein precursor molecules. The ability of the various endogenous agonists to differentially couple these receptors to different second messengers and ion channels will be assessed.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Cells RoPA (CELL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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