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Structure/function analysis of receptor-regulated plasma membrane calcium channels
Reference
CEL04687
Principal Investigator / Supervisor
Professor John B C Findlay
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
137,289
Status
Completed
Type
Research Grant
Start date
01/12/1995
End date
30/05/1999
Duration
42 months
Abstract
A novel receptor-regulated Ca channel will be studied. Homologues from mammalian cell systems will be cloned and analysed. The intact protein and constituent domains will be expressed, in native and mutant forms and their structures and functions investigated with respect to transport properties, intra- and inter-domain association, interaction with cytoskeletal elements, binding of regulatory proteins and second messengers and biological modification. The project may identify an important missing mammalian protein and establish new approaches to channel structure/function analysis.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Cells RoPA (CELL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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