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Characterisation of Salmonella-induced macrophage lysis and its role in Salmonella host-specificity
Reference
CEL04652
Principal Investigator / Supervisor
Dr Timothy Wallis
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Immunology Compton
Funding type
Research
Value (£)
134,893
Status
Completed
Type
Research Grant
Start date
01/10/1995
End date
01/10/1998
Duration
36 months
Abstract
The persistence of strains of S. dublin and S. cholerae-suis with and without virulence plasmids in macrophage from cattle and pigs will be compared. The cytotoxicity of these strains for the different macrophage populations will be quantified. Plasmid genes mediating cytotoxicity will be identified by transposon mutagenesis and sub-cloning. The impact of swapping plasmids between serotypes on macrophage cytotoxicity and virulence in cattle and pigs will be assessed.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Cells RoPA (CELL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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