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The interaction of genotype and mechanical loading on cartilage homeostasis and function
Reference
CEL04636
Principal Investigator / Supervisor
Professor Colin Farquharson
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
122,050
Status
Completed
Type
Research Grant
Start date
13/11/1995
End date
13/11/1998
Duration
36 months
Abstract
The roles of genotype and functional loading in articular cartilage metabolism, and in degenerative joint disorders, is poorly understood. This study examines responses in articular cartilage to mechanical stimulation. Chondrocyte function will be examined by measuring matrix proteins turnover and growth factors expression. Comparison of articular cartilage samples from different sites in broiler fowl (inactive and prone to degenerative joint disease) and in laying strain fowl (active with little joint disease) will enable assessment of the effects of phenotype and genotype on the responses to mechanical stimulation, providing new insights into the role of functional activity in articular cartilage homeostasis and function.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Cells RoPA (CELL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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