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Harnessing of RNA recombination to produce antigenic and pathotypic variants of coronavirus IBV

Reference	CEL04623
Principal Investigator / Supervisor	Professor David Cavanagh
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	Div of Molecular Biology Pirbright
Funding type	Research
Value (£)	126,670
Status	Completed
Type	Research Grant
Start date	01/11/1995
End date	01/11/1998
Duration	36 months

Abstract

The 5' and 3' genomic sequences essential for replication of infectious bronchitis virus (IBV) RNA will be identified. These sequences will be used to flank cDNAs corresponding to selected IBV genes. These constructs will be cloned into a fowlpox virus recombinant. Expression from a T7 promoter will produce an RNA vector that will be replicated and recombine with the helper IBV. This approach will produce site directed recombinants to study antigenicity and pathogenicity.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Cells RoPA (CELL) [1994]
Funding Scheme	X – not Funded via a specific Funding Scheme

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