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Afferent transduction of nutrient signals from the gastrointestinal lumen
Reference
CEL04609
Principal Investigator / Supervisor
Professor David Grundy
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Biomedical Science
Funding type
Research
Value (£)
158,516
Status
Completed
Type
Research Grant
Start date
16/10/1995
End date
16/10/1998
Duration
36 months
Abstract
This project aims to investigate the transduction mechanisms which underlie activation of mucosal afferents by nutrients within the GI lumen. Electrophysiological and immunocytochemical methods will be employed to examine the role of enteroendocrine cells, which are strategically positioned at the interface between lumen and afferent. An in vitro intestinal preparation, allowing the receptor environment to be rigorously controlled, will be employed to investigate the stimulus-response characteristics of mucosal afferents to dietary carbohydrates, protein and fats, using protocols designed to distinguish between pre- and post- absorption recognition sites. The project will provide insight into the basic mechanisms of nutrient recognition.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Cells RoPA (CELL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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