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The function of P-glycoproteins in higher plants

Reference	CEL04600
Principal Investigator / Supervisor	Dr Stephen Moss
Co-Investigators / Co-Supervisors
Institution	Rothamsted Research
Department	Agro-Ecology
Funding type	Research
Value (£)	123,628
Status	Completed
Type	Research Grant
Start date	31/01/1996
End date	31/01/1999
Duration	36 months

Abstract

P-glycoproteins can act as ATP-dependent membrane efflux pumps conferring multi-drug resistance to mammalian tumours. Genes encoding similar proteins have recently been isolated from plants, but the role of these gene products in plant metabolism is unknown. Striking parallels exist between the phenomenon of multi-drug resistance in animal cells and certain types of cross-resistance to herbicides in grass weeds. Such resistant biotypes will be used to investigate any correlation between P-glycoprotein expression and herbicide resistance. The physiological function(s) of P-glycoproteins in this and other aspects of plant metabolism will be investigated using isolated membranes and appropriate expression systems.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Cells RoPA (CELL) [1994]
Funding Scheme	X – not Funded via a specific Funding Scheme

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