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Analysis of desmosomal adhesion and its role in cellular invasion and motility
Reference
CEL04596
Principal Investigator / Supervisor
Professor David Garrod
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
118,422
Status
Completed
Type
Research Grant
Start date
01/04/1996
End date
01/04/1999
Duration
36 months
Abstract
Non-adhesive cells will be transfected with combinations of cDNAs for glycoprotein and protein components of the adhesive intercellular junctions known as desmosomes, and the effect on cell behaviour in aggregation, invasion and motility assays measured. In this way the functional co-operation between molecular desmosomal components and the role of desmosomal adhesion in regulating all behaviour will be assessed. The results will have significance in relation to normal development, normal tissue structure and several diseases.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Cells RoPA (CELL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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