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Electrical properties of bacterial transport proteins
Reference
CEL04592
Principal Investigator / Supervisor
Professor Peter Henderson
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
113,575
Status
Completed
Type
Research Grant
Start date
06/01/1996
End date
06/01/1999
Duration
36 months
Abstract
The aim is to characterise trans-membrane electrical gradients generated by bacterial transport proteins and their mutants, using biomembrane vesicles, synthetic bilayer membranes, proteoliposomes, patch-clamping, ionophores, optical indicators and, possibly, oocytes. The results will illuminate the molecular mechanisms of charge translocation by proteins, and show how gradients of sugars, glucuronides, antibiotics, antiseptics, nucleosides and other substrates are mutually transducible with electrochemical ion gradients across biological membranes. Foundations may be laid for a new generation of biosensors and components for bioelectronic circuitry.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Cells RoPA (CELL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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