Award details

The production of influenza viruses dependent on complementing cell lines

Reference	CEL04569
Principal Investigator / Supervisor	Dr John McCauley
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	Div of Molecular Biology Pirbright
Funding type	Research
Value (£)	139,570
Status	Completed
Type	Research Grant
Start date	12/02/1996
End date	12/02/1999
Duration	36 months

Abstract

Cell lines which express influenza virus haemagglutinin will be used to complement the functions of virus encoded HA and allow the production of influenza virus with a defective or a missing HA gene. Engineered artificial defective HA genes in vitro will be made and their packaging into progeny virus will be examined. The potential of the HA(-) virus to act as an attenuated vaccine capable of only a single round of virus replication in the host and as a gene delivery vector will be assessed.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Cells RoPA (CELL) [1994]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search