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The structure and functions of the murine leukaemia virus matrix protein
Reference
CEL04559
Principal Investigator / Supervisor
Dr A Kingsman
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Biochemistry
Funding type
Research
Value (£)
130,906
Status
Completed
Type
Research Grant
Start date
01/10/1995
End date
01/10/1998
Duration
36 months
Abstract
Despite the central position of murine leukemia virus (MLV) in gene transfer technology there are no structures available for its major components. As a first step towards rectifying this situation, we will determine the structure of the MLV matrix position. This protein orchestrates virus assembly. We will take a multidisciplinary approach using genetic and biophysical (NMR/XRD) strategies. This study will contribute to our basic understanding of retroviruses and it will lead to the manipulation of gene delivery system in various ways. This will be of interest to the bio-industries where selective gene delivery will become increasingly important.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Cells RoPA (CELL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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