Award details

Development of Mortierella alpina for production of polyunsaturated fatty acids

ReferenceCE08125
Principal Investigator / Supervisor Professor David Archer
Co-Investigators /
Co-Supervisors
Professor Colin Ratledge
Institution Quadram Institute Bioscience
DepartmentFood Safety Science Division
Funding typeResearch
Value (£) 276,205
StatusCompleted
TypeResearch Grant
Start date 01/04/1998
End date 01/04/2001
Duration36 months

Abstract

This project aims to investigate the biochemistry and molecular genetics of fatty acid desaturation and elongation in Mortierella alpina, a filamentous fungus that accumulates polyunsaturated fatty acids (PUFAs). Specific objectives are to establish the biochemical basis for fatty acid elongation from C18:3 to C20:3 and desaturation (delta 5, delta 6, delta 12). Available M. alpina mutants that overproduce PUFAs, and mutants that will be generated, will be used to clone elongase and desaturase genes. The genes will be used to genetically manipulate M. alpina to improve the yields of PUFAs, to alter the range of PUFAs and to produce strains able to utilise vegetable oils as a substrate for PUFA biosynthesis.

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Cell Engineering - GDB Committee (CE) [1994-1996]
Funding SchemeX – not Funded via a specific Funding Scheme
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