Award details

Engineering of plant cells for the production of vaccines (green vaccines)

Reference	CE07441
Principal Investigator / Supervisor	Professor George Lomonossoff
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	148,055
Status	Completed
Type	Research Grant
Start date	01/12/1997
End date	01/12/2000
Duration	36 months

Abstract

To overcome the regulatory problems associated with using genetically modified particles of the plant pathogen, cowpea mosaic virus (CPMV), as novel oral vaccines, complementation systems for the production of non-infectious chimaeric virus particles (CVPs) will be established. Lines of plants transgenic for essential virus genes will be generated and the ability of viral genomes deleted in these genes to replicate in such plants will be determined. The resulting CVPs will contain deleted forms of the viral RNA and will therefore be unable to infect non-transformed plants, abolishing their ability to spread in the environment. The systems will be evaluated for commercial exploitation by our industrial partner.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Cell Engineering - GDB Committee (CE) [1994-1996]
Funding Scheme	X – not Funded via a specific Funding Scheme

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