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Engineering resistance to nematodes by controlled and specific plant attenuation
Reference
CE06537
Principal Investigator / Supervisor
Professor Michael McPherson
Co-Investigators /
Co-Supervisors
Prof. Howard Atkinson
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
157,446
Status
Completed
Type
Research Grant
Start date
15/02/1997
End date
14/08/2000
Duration
42 months
Abstract
Effector sequences will be developed to attenuate or destroy any plant cell modified by a cyst-nematode to form its feeding site. Controlled expression will be provided using previously characterised promoters. Both single molecule and binary effectors will be developed for both a sole and a pyramided defence. Comparisons will be made of the efficacy of: (i) engineered RNAse variants, (ii) transcript-specific RNAse P variants, (iii) antisense inhibition of metabolically critical genes and (iv) expression of ribosomal inactivation proteins. Efficacy of resistance will be established for favoured promoter/effector constructs by challenging transgenic potato plants with cyst-nematodes.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Cell Engineering - GDB Committee (CE) [1994-1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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